Photocontrollable NO-releasing compounds and their biological applications
نویسنده
چکیده
Photocontrollable nitric oxide (NO)-releasing compounds, or caged NOs, are very useful to expose cells or tissues to NO in a spatiotemporally well-controlled manner, e.g., for precise investigations of biological responses to NO and NO-related signaling pathways. We have developed photocontrollable NO releasers based on two mechanisms: photoinduced isomerization reaction of a dimethylnitrobenzene moiety conjugated with a pi-electron system, and photoinduced electron transfer of a moderately electron-rich N-nitroso aminophenol moiety linked with an antenna dye moiety. In this review, we describe the development of our photoinduced NO releasers based on these mechanisms, and present examples of cellular and ex vivo applications.
منابع مشابه
Photocontrollable fluorescent proteins for superresolution imaging.
Superresolution fluorescence microscopy permits the study of biological processes at scales small enough to visualize fine subcellular structures that are unresolvable by traditional diffraction-limited light microscopy. Many superresolution techniques, including those applicable to live cell imaging, utilize genetically encoded photocontrollable fluorescent proteins. The fluorescence of these ...
متن کاملActive Packaging for Food Applications - A Review
The purpose of food packaging is to preserve the quality and safety of the food it contains from the time of manufacture to the time it is used by the consumer. Recently, the demand for safe and high quality foods, as well as changes in consumer preferences have led to the development of innovative and novel approaches in food packaging technology. One such development is the active food packag...
متن کاملPhotoinduced upregulation of calcitonin gene-related peptide in A549 cells through HNO release from a hydrophilic photocontrollable HNO donor.
Nitroxyl (HNO), a one-electron-reduced form of nitric oxide, has various biological activities, including a cardioprotective effect. Here, we first synthesized another, more hydrophilic photocontrollable HNO donor (3), which can release HNO in a spatially and temporally controlled manner, and then examined the properties of our series of compounds as practical HNO donors in a cellular system un...
متن کاملActive Packaging for Food Applications - A Review
The purpose of food packaging is to preserve the quality and safety of the food it contains from the time of manufacture to the time it is used by the consumer. Recently, the demand for safe and high quality foods, as well as changes in consumer preferences have led to the development of innovative and novel approaches in food packaging technology. One such development is the active food packag...
متن کاملOptical and Physical Applications of Photocontrollable Materials: Azobenzene-Containing and Liquid Crystalline Polymers
Photocontrol of molecular alignment is an exceptionally-intelligent and useful strategy. It enables us to control optical coefficients, peripheral molecular alignments, surface relief structure, and actuation of substances by means of photoirradiation. Azobenzene-containing polymers and functionalized liquid crystalline polymers are well-known photocontrollable materials. In this paper, we intr...
متن کامل